Meropenem Injection

Description

Product Description: Meropenem Injection is a broad-spectrum antibiotic used to treat severe bacterial infections. It belongs to the carbapenem class of antibiotics and is highly effective against a wide range of gram-positive and gram-negative bacteria. Meropenem is a vital therapeutic option for complicated infections where resistance is a concern.

Indications and Usage: Meropenem Injection is indicated for the treatment of serious infections caused by susceptible organisms, including intra-abdominal infections, bacterial meningitis, complicated skin and skin structure infections, and nosocomial pneumonia.

Dosage and Administration: Dosage and administration should be determined by a qualified healthcare professional based on factors such as the severity of the infection, the patient's age and weight, and the susceptibility of the causative bacteria. Meropenem is typically administered intravenously over a period of 15 to 30 minutes.

Dosage Forms and Strengths: Meropenem Injection is available as a sterile powder for reconstitution in various strengths, typically ranging from 500 mg to 2 grams per vial.

Contraindications: Meropenem Injection is contraindicated in patients with known hypersensitivity to carbapenems or any component of the formulation. It should not be used in patients with a history of severe allergic reactions to beta-lactam antibiotics.

Warnings and Precautions: Serious hypersensitivity reactions, including anaphylaxis, have been reported with the use of meropenem. It should be used with caution in patients with a history of allergies, asthma, or other allergic conditions. Prolonged use may result in the overgrowth of non-susceptible organisms, including fungi. Clostridium difficile-associated diarrhea has been reported with the use of nearly all antibacterial agents, including meropenem.

Adverse Reactions/Side Effects: Common adverse reactions associated with meropenem include diarrhea, nausea, vomiting, headache, and injection site reactions. Serious adverse reactions may include severe allergic reactions, Clostridium difficile-associated diarrhea, and seizures.

Drug Interactions: Meropenem may interact with other medications, including valproic acid, which may reduce valproic acid levels. Concurrent use with probenecid may increase meropenem plasma concentrations. Caution should be exercised when co-administering with other drugs that may affect renal function.

Use In Specific Populations Description: Use of meropenem in pregnant women should be weighed against the potential risks to the fetus. It is excreted in breast milk; caution should be exercised when administering to nursing mothers. Safety and efficacy in pediatric patients have been established for certain indications and age groups.

How Supplied/Storage and Handling: Meropenem Injection is supplied as a sterile powder in single-dose vials. It should be stored at controlled room temperature (20°C to 25°C) and protected from light. Reconstituted solutions should be used immediately or stored under refrigeration for up to 24 hours.