Thiopental Injection

Description

Product Description: Thiopental Injection is a sterile solution used for intravenous administration. It belongs to the class of medications known as barbiturates and is primarily utilized as an anesthetic agent for induction of anesthesia or for the treatment of certain conditions such as status epilepticus.

Indications and Usage: Thiopental Injection is indicated for the induction of anesthesia, particularly for short surgical procedures where rapid onset and short duration of action are desired. It is also used in the management of status epilepticus, severe convulsive seizures that are resistant to other therapies.

Dosage and Administration: The dosage of Thiopental Injection varies based on the patient's age, weight, and medical condition. For induction of anesthesia, the typical adult dose is 100 to 150 mg administered intravenously over 10 to 20 seconds. For status epilepticus, higher doses may be required, usually administered as a slow intravenous infusion.

Dosage Forms and Strengths: Thiopental Injection is available as a sterile solution in vials for intravenous administration. It is commonly supplied in concentrations of 0.5 g/2.5 mL or 1 g/5 mL.

Contraindications: Thiopental Injection is contraindicated in patients with known hypersensitivity to barbiturates or any component of the formulation. It should not be used in patients with porphyria, severe respiratory depression, or severe liver disease.

Warnings and Precautions: Use caution when administering Thiopental Injection to patients with impaired cardiovascular function, respiratory depression, or compromised liver function. Rapid injection may lead to respiratory depression, hypotension, or cardiac arrest. Avoid use in elderly or debilitated patients due to increased sensitivity to the effects of barbiturates.

Adverse Reactions/Side Effects: Common adverse reactions associated with Thiopental Injection include respiratory depression, hypotension, bradycardia, and laryngospasm. Other side effects may include nausea, vomiting, headache, or allergic reactions. Serious adverse effects such as paradoxical reactions, including excitement, agitation, or hallucinations, may occur.

Drug Interactions: Thiopental Injection may interact with other central nervous system depressants, such as benzodiazepines, opioids, or alcohol, leading to additive effects on sedation and respiratory depression. Concurrent use with medications that affect liver enzyme activity may alter the metabolism of thiopental.

Use In Specific Populations Description: Safety and efficacy of Thiopental Injection in pediatric patients, pregnant women, and nursing mothers have not been established. Use caution and consult with a healthcare professional before administering to individuals in these populations.

How Supplied/Storage and Handling: Thiopental Injection is supplied as a sterile solution in vials for intravenous administration. It should be stored at controlled room temperature (20°C to 25°C) away from light and moisture. Care should be taken to ensure proper storage and handling to maintain the integrity of the product. Unused portions should be discarded according to standard procedures for biohazardous waste.