Teicoplanin Injection

Description

Product Description: Teicoplanin Injection is a potent antibiotic belonging to the glycopeptide class, derived from Actinoplanes teichomyceticus. It is used for the treatment of severe bacterial infections, particularly those caused by gram-positive organisms. Teicoplanin Injection is a critical therapeutic option for infections where resistance to other antibiotics is a concern.

Indications and Usage: Teicoplanin Injection is indicated for the treatment of serious infections caused by susceptible gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), Staphylococcus epidermidis, Streptococcus pneumoniae, and Enterococcus faecalis.

Dosage and Administration: Dosage and administration should be determined by a qualified healthcare professional based on factors such as the severity of the infection, the patient's weight, renal function, and the susceptibility of the causative bacteria. Teicoplanin is typically administered intravenously or intramuscularly.

Dosage Forms and Strengths: Teicoplanin Injection is available as a sterile powder for reconstitution in various strengths, typically ranging from 200 mg to 600 mg per vial.

Contraindications: Teicoplanin Injection is contraindicated in patients with known hypersensitivity to teicoplanin or any component of the formulation. It should not be used in patients with a history of severe allergic reactions to glycopeptide antibiotics.

Warnings and Precautions: Serious hypersensitivity reactions, including anaphylaxis, have been reported with the use of teicoplanin. It should be used with caution in patients with a history of allergies, asthma, or other allergic conditions. Prolonged use may result in the overgrowth of non-susceptible organisms, including fungi. Clostridium difficile-associated diarrhea has been reported with the use of nearly all antibacterial agents, including teicoplanin.

Adverse Reactions/Side Effects: Common adverse reactions associated with teicoplanin include diarrhea, nausea, vomiting, rash, and injection site reactions. Serious adverse reactions may include severe allergic reactions, nephrotoxicity, and thrombocytopenia.

Drug Interactions: Teicoplanin may interact with other medications, including nephrotoxic drugs such as aminoglycosides and loop diuretics, which may increase the risk of kidney damage. Concurrent use with other drugs that affect renal function may also increase the risk of nephrotoxicity.

Use In Specific Populations Description: Use of teicoplanin in pregnant women should be weighed against the potential risks to the fetus. It is excreted in breast milk; caution should be exercised when administering to nursing mothers. Safety and efficacy in pediatric patients have been established for certain indications and age groups.

How Supplied/Storage and Handling: Teicoplanin Injection is supplied as a sterile powder in single-dose vials. It should be stored at controlled room temperature (20°C to 25°C) and protected from light. Reconstituted solutions should be used immediately or stored under refrigeration for up to 24 hours.