Succinylcholine Chloride Injection
- Packing: 2 Ml Ampoule.
- Available Strength : 50 Mg/Ml
Description
Product Description: Succinylcholine Chloride Injection is a sterile solution containing succinylcholine chloride, a depolarizing neuromuscular blocking agent. It is indicated for the induction of skeletal muscle relaxation and facilitation of endotracheal intubation during surgical procedures and mechanical ventilation in intensive care settings.
Indications and Usage: Succinylcholine Chloride Injection is indicated as an adjunct to general anesthesia to induce skeletal muscle relaxation and facilitate endotracheal intubation. It is used during surgical procedures, electroconvulsive therapy (ECT), and mechanical ventilation in intensive care units (ICUs) to provide temporary paralysis of skeletal muscles.
Dosage and Administration: The dosage of Succinylcholine Chloride Injection is based on the patient's weight, age, and clinical condition. It is administered intravenously at a recommended initial dose of 0.6 to 1.1 mg/kg for adults and 2 mg/kg for pediatric patients. Additional doses may be administered as needed based on the patient's response and the duration of muscle relaxation required.
Dosage Forms and Strengths: Succinylcholine Chloride Injection is available as a sterile solution in vials or ampules for intravenous administration. Each milliliter of the solution contains a specified amount of succinylcholine chloride, typically expressed in milligrams per milliliter (mg/mL).
Contraindications: Succinylcholine Chloride Injection is contraindicated in patients with a known hypersensitivity to succinylcholine chloride or any component of the formulation. It should not be used in patients with a history of malignant hyperthermia, severe hyperkalemia, or significant skeletal muscle myopathies.
Warnings and Precautions: Use caution when administering Succinylcholine Chloride Injection to patients with a history of neuromuscular disorders, including myasthenia gravis, Eaton-Lambert syndrome, or myopathies. Prolonged use or repeated doses may increase the risk of muscle fasciculations, myalgias, or hyperkalemia. Monitor patients closely for signs of respiratory depression, apnea, or malignant hyperthermia.
Adverse Reactions/Side Effects: Common adverse reactions associated with Succinylcholine Chloride Injection may include transient bradycardia, tachycardia, hypertension, hypotension, respiratory depression, bronchospasm, and allergic reactions such as rash or itching. Rare but serious adverse reactions may include malignant hyperthermia, hyperkalemia, prolonged paralysis, and postoperative muscle pain.
Drug Interactions: Succinylcholine Chloride Injection may interact with certain medications, including cholinesterase inhibitors, local anesthetics, and volatile anesthetics. Concurrent use may potentiate or prolong the effects of succinylcholine chloride, leading to increased neuromuscular blockade or respiratory depression. Adjust the dosage of concomitant medications as necessary and monitor patients closely for signs of drug interactions.
Use In Specific Populations Description: Safety and efficacy of Succinylcholine Chloride Injection in pediatric patients, elderly patients, pregnant women, and nursing mothers have not been established conclusively. Use caution and individualize the dosage and administration based on the patient's age, weight, and medical condition.
How Supplied/Storage and Handling: Succinylcholine Chloride Injection is supplied as a sterile solution in vials or ampules for intravenous administration. It should be stored at controlled room temperature (20°C to 25°C) away from light and moisture. Care should be taken to ensure proper storage and handling to maintain the integrity of the product. Unused portions should be discarded according to standard procedures for biohazardous waste.