Piperacillin + Tazobactam Injection

Description

Product Description: Piperacillin + Tazobactam Injection is a potent combination antibiotic comprising piperacillin, a broad-spectrum penicillin, and tazobactam, a beta-lactamase inhibitor. This synergistic combination offers enhanced efficacy against a wide range of bacterial infections, making it a valuable therapeutic option for serious infections where resistance is a concern.

Indications and Usage: Piperacillin + Tazobactam Injection is indicated for the treatment of moderate to severe infections caused by susceptible organisms, including intra-abdominal infections, skin and soft tissue infections, pneumonia, and urinary tract infections.

Dosage and Administration: Dosage and administration should be determined by a qualified healthcare professional based on factors such as the severity of the infection, the patient's age and weight, renal function, and the susceptibility of the causative bacteria. Piperacillin + Tazobactam is typically administered intravenously over a period of 30 minutes to 1 hour.

Dosage Forms and Strengths: Piperacillin + Tazobactam Injection is available as a sterile powder for reconstitution in various strengths, typically ranging from 2.25 grams to 4.5 grams per vial.

Contraindications: Piperacillin + Tazobactam Injection is contraindicated in patients with known hypersensitivity to penicillins, cephalosporins, or any component of the formulation. It should not be used in patients with a history of severe allergic reactions to beta-lactam antibiotics.

Warnings and Precautions: Serious hypersensitivity reactions, including anaphylaxis, have been reported with the use of piperacillin + tazobactam. It should be used with caution in patients with a history of allergies, asthma, or other allergic conditions. Prolonged use may result in the overgrowth of non-susceptible organisms, including fungi. Clostridium difficile-associated diarrhea has been reported with the use of nearly all antibacterial agents, including piperacillin + tazobactam.

Adverse Reactions/Side Effects: Common adverse reactions associated with piperacillin + tazobactam include diarrhea, nausea, vomiting, rash, and injection site reactions. Serious adverse reactions may include severe allergic reactions, Clostridium difficile-associated diarrhea, and hepatic dysfunction.

Drug Interactions: Piperacillin + Tazobactam may interact with other medications, including aminoglycosides, which may potentiate nephrotoxicity. Concurrent use with loop diuretics may increase the risk of nephrotoxicity. Caution should be exercised when co-administering with other nephrotoxic drugs.

Use In Specific Populations Description: Use of piperacillin + tazobactam in pregnant women should be weighed against the potential risks to the fetus. It is excreted in breast milk; caution should be exercised when administering to nursing mothers. Safety and efficacy in pediatric patients have been established for certain indications and age groups.

How Supplied/Storage and Handling: Piperacillin + Tazobactam Injection is supplied as a sterile powder in single-dose vials. It should be stored at controlled room temperature (20°C to 25°C) and protected from light. Reconstituted solutions should be used immediately or stored under refrigeration for up to 24 hours.