Papaverine Injection
- Packing: 2 Ml Ampoule.
- Available Strength : 30 Mg/Ml
Description
Product Description: Papaverine Injection is a sterile solution containing the active ingredient papaverine hydrochloride, which belongs to the class of medications known as vasodilators. It is used for its smooth muscle relaxant properties to treat conditions such as vasospasm, erectile dysfunction, and certain vascular disorders.
Indications and Usage: Papaverine Injection is indicated for the treatment of vasospasm associated with conditions such as coronary artery disease, peripheral vascular disease, and Raynaud's phenomenon. It is also used in the management of erectile dysfunction by promoting penile vasodilation and enhancing blood flow to the penis.
Dosage and Administration: The dosage of Papaverine Injection varies depending on the patient's age, weight, and the condition being treated. It is administered by intravenous, intramuscular, or intra-arterial injection. The recommended dosage typically ranges from 30 to 120 mg, administered as a single dose or in divided doses as directed by a healthcare professional.
Dosage Forms and Strengths: Papaverine Injection is available as a sterile solution in vials or ampules for intravenous, intramuscular, or intra-arterial administration. Each milliliter of the solution typically contains a specified amount of papaverine hydrochloride, typically expressed in milligrams per milliliter (mg/mL).
Contraindications: Papaverine Injection is contraindicated in patients with a known hypersensitivity to papaverine or any component of the formulation. It should not be used in patients with severe hepatic or renal impairment, hypotension, or a history of priapism.
Warnings and Precautions: Use caution when administering Papaverine Injection to patients with underlying cardiovascular disorders, hypotension, or impaired hepatic or renal function. Prolonged or excessive use may increase the risk of adverse cardiovascular effects, including hypotension, palpitations, and arrhythmias. Monitor patients closely for signs of worsening symptoms or adverse reactions during treatment.
Adverse Reactions/Side Effects: Common adverse reactions associated with Papaverine Injection may include dizziness, headache, flushing, nausea, vomiting, and hypotension. Rare but serious adverse reactions may include allergic reactions such as rash, pruritus, or anaphylaxis.
Drug Interactions: Papaverine Injection may interact with certain medications, including other vasodilators, antihypertensive agents, and phosphodiesterase inhibitors. Concurrent use may potentiate or antagonize the effects of papaverine, leading to increased or decreased vasodilation. Adjust the dosage of concomitant medications as necessary and monitor patients closely for signs of drug interactions.
Use In Specific Populations Description: Safety and efficacy of Papaverine Injection in pediatric patients, elderly patients, pregnant women, and nursing mothers have not been established conclusively. Use caution and individualize the dosage and administration based on the patient's age, weight, and medical condition.
How Supplied/Storage and Handling: Papaverine Injection is supplied as a sterile solution in vials or ampules for intravenous, intramuscular, or intra-arterial administration. It should be stored at controlled room temperature (20°C to 25°C) away from light and moisture. Care should be taken to ensure proper storage and handling to maintain the integrity of the product. Unused portions should be discarded according to standard procedures for biohazardous waste.