Mifepristone Tablets
- Packing: 1 x1 Tablet
- Available Strength : 200 Mg
Description
Product Description: Mifepristone Tablets contain the active ingredient mifepristone, a synthetic steroid with antiprogesterone properties. It is primarily used for medical abortion in combination with misoprostol.
Indications and Usage: Mifepristone Tablets are indicated for the medical termination of intrauterine pregnancy up to 70 days of gestation. It is also used for the management of hyperglycemia secondary to hypercortisolism in patients with endogenous Cushing's syndrome who have type 2 diabetes mellitus or glucose intolerance and have failed surgery or are not candidates for surgery.
Dosage and Administration: The dosage and administration regimen for Mifepristone Tablets may vary depending on the specific indication. For medical abortion, a typical regimen involves the administration of 200 mg of mifepristone orally, followed by the administration of misoprostol within 24 to 48 hours. For the management of hyperglycemia in patients with endogenous Cushing's syndrome, the recommended dosage is 300 mg daily for a maximum of 24 weeks.
Dosage Forms and Strengths: Mifepristone Tablets are available in oral tablet form, typically containing 200 mg of mifepristone.
Contraindications: Mifepristone Tablets are contraindicated in patients with confirmed or suspected ectopic pregnancy, chronic adrenal failure, inherited porphyrias, and concurrent long-term corticosteroid therapy. It is also contraindicated in patients with a known hypersensitivity to mifepristone or any of its components.
Warnings and Precautions: Patients should be monitored closely for signs of incomplete abortion, excessive bleeding, and other complications following the administration of Mifepristone Tablets for medical abortion. In patients with endogenous Cushing's syndrome, close monitoring of glucose levels and adrenal function is necessary during treatment with mifepristone.
Adverse Reactions/Side Effects: Common adverse reactions associated with Mifepristone Tablets may include abdominal pain, uterine cramping, vaginal bleeding, nausea, vomiting, and diarrhea. Less common but serious side effects may include allergic reactions, hemorrhage, and infection.
Drug Interactions: Mifepristone may interact with certain medications, including corticosteroids, anticoagulants, anticonvulsants, and drugs that are substrates of cytochrome P450 3A4 enzymes, potentially altering their efficacy or increasing the risk of adverse effects.
Use In Specific Populations Description: Mifepristone Tablets should be used with caution in patients with a history of cardiovascular disease, hypertension, or hepatic impairment. It is not recommended for use during pregnancy or breastfeeding unless absolutely necessary.
How Supplied/Storage and Handling: Mifepristone Tablets are typically supplied in blister packs or bottles, with specific packaging details varying depending on the manufacturer. They should be stored at room temperature (20°C to 25°C) away from moisture and heat. Unused tablets should be properly disposed of according to local regulations.
