Medroxyprogesterone Injection Suspension
- Packing: 1 Ml Vial
- Available Strength : 150 Mg/Ml
Description
Product Description: Medroxyprogesterone Injection Suspension is a pharmaceutical formulation containing medroxyprogesterone acetate, a synthetic progestin hormone. It is indicated for various medical conditions where hormonal therapy is necessary, including abnormal uterine bleeding, endometriosis, and certain types of cancer. This injection provides a convenient and effective way to administer medroxyprogesterone acetate for therapeutic purposes.
Indications and Usage: Medroxyprogesterone Injection Suspension is indicated for the treatment of abnormal uterine bleeding due to hormonal imbalance, such as dysfunctional uterine bleeding or uterine fibroids. It is also used in the management of endometriosis to alleviate symptoms such as pelvic pain and dysmenorrhea. Additionally, it may be used as an adjunctive therapy in the palliative treatment of certain types of cancer, such as endometrial or renal carcinoma.
Dosage and Administration: The dosage of Medroxyprogesterone Injection Suspension varies depending on the patient's condition, weight, and response to therapy. It is administered via intramuscular injection under the supervision of a healthcare professional. The injection site should be rotated to minimize the risk of local tissue irritation. The dosage regimen should be individualized based on the patient's clinical response and any underlying medical conditions.
Dosage Forms and Strengths: Medroxyprogesterone Injection Suspension is available as a sterile suspension in single-dose vials. Each mL of suspension contains medroxyprogesterone acetate equivalent to 150 mg of medroxyprogesterone.
Contraindications: Medroxyprogesterone Injection Suspension is contraindicated in patients with known or suspected pregnancy, active thrombophlebitis or thromboembolic disorders, undiagnosed vaginal bleeding, or hypersensitivity to medroxyprogesterone acetate or any of the excipients. It should not be used in patients with a history of breast cancer or other hormone-sensitive malignancies.
Warnings and Precautions: Administration of Medroxyprogesterone Injection Suspension requires careful monitoring of the patient's clinical response and any signs of adverse effects. It should be used with caution in patients with a history of depression or other psychiatric disorders, as it may exacerbate these conditions. Long-term use may be associated with a loss of bone mineral density; therefore, periodic evaluation of bone health is recommended.
Adverse Reactions/Side Effects: Common adverse reactions associated with Medroxyprogesterone Injection Suspension include irregular menstrual bleeding, amenorrhea, headache, and breast tenderness. Rare but serious adverse reactions may include thromboembolic events, such as deep vein thrombosis or pulmonary embolism, or allergic reactions such as rash or pruritus. If any adverse reactions occur, the injection should be discontinued, and appropriate medical treatment initiated.
Drug Interactions: Medroxyprogesterone Injection Suspension may interact with other medications that affect hormonal balance or liver metabolism, such as anticonvulsants, corticosteroids, or certain antiretroviral drugs. Concurrent use with hormonal contraceptives may alter the effectiveness of both medications. Close monitoring is recommended when administering medroxyprogesterone with other drugs affecting the coagulation cascade or liver function.
Use In Specific Populations Description: The safety and efficacy of Medroxyprogesterone Injection Suspension in pediatric patients, geriatric patients, and pregnant or lactating women have not been established. Use with caution in these populations, and only if the potential benefits outweigh the risks. Close monitoring is recommended in patients with renal or hepatic impairment.
How Supplied/Storage and Handling: Medroxyprogesterone Injection Suspension is supplied as a sterile suspension in single-dose vials. It should be stored at controlled room temperature between 20°C to 25°C (68°F to 77°F), protected from light and moisture. Do not freeze. Discard any unused portion of the suspension.