L-Carnitine Injection
- Packing: 5 Ml Ampoule.
- Available Strength : 200 Mg/Ml
Description
Product Description: L-Carnitine Injection is a sterile solution containing L-carnitine, a naturally occurring amino acid derivative involved in energy metabolism. L-carnitine plays a crucial role in the transportation of fatty acids into mitochondria, where they are metabolized to produce energy. This injection form offers a convenient and rapid means of administration for individuals with conditions that require supplemental L-carnitine.
Indications and Usage: L-Carnitine Injection is indicated for the treatment of carnitine deficiency syndromes, including primary systemic carnitine deficiency, secondary carnitine deficiency, and certain metabolic disorders such as mitochondrial disorders and fatty acid oxidation disorders. It is also used as a supplement in patients undergoing hemodialysis to prevent or correct carnitine deficiency.
Dosage and Administration: The dosage of L-Carnitine Injection depends on the patient's age, weight, medical condition, and severity of deficiency. It is typically administered intravenously or intramuscularly. The recommended dosage for adults with carnitine deficiency is usually 1 to 2 grams (1000-2000 mg) per day, divided into multiple doses. Pediatric dosing should be determined based on the child's weight and clinical status.
Dosage Forms and Strengths: L-Carnitine Injection is available as a sterile solution in vials or ampules for parenteral administration. Each mL of solution typically contains 200 mg to 1000 mg of L-carnitine, depending on the concentration of the formulation. It is supplied in various packaging sizes to accommodate different clinical settings and patient needs.
Contraindications: L-Carnitine Injection is contraindicated in patients with a known hypersensitivity to L-carnitine or any component of the formulation. It should not be used in patients with trimethylaminuria (fish odor syndrome) or carnitine palmitoyltransferase II deficiency. Use caution in patients with renal impairment or hepatic dysfunction.
Warnings and Precautions: Use caution when administering L-Carnitine Injection to patients with renal impairment, as accumulation of carnitine may occur. Monitor renal function regularly and adjust the dosage as necessary. Use with caution in pregnant or breastfeeding women, as safety data in these populations are limited. Exercise caution when using L-Carnitine Injection in patients with a history of seizures or cardiovascular disease.
Adverse Reactions/Side Effects: Common adverse reactions associated with L-Carnitine Injection may include gastrointestinal disturbances such as nausea, vomiting, diarrhea, and abdominal cramps. Less common side effects may include headache, dizziness, and allergic reactions such as rash or pruritus. Severe adverse reactions are rare but may include anaphylaxis or exacerbation of preexisting conditions.
Drug Interactions: L-Carnitine Injection may interact with certain medications, including anticoagulants, thyroid hormones, and valproic acid. Concurrent use may potentiate the effects of these medications or alter their metabolism. Monitor patients closely for signs of drug interactions and adjust the dosage of concomitant medications as necessary.
Use In Specific Populations Description: Safety and efficacy of L-Carnitine Injection in pediatric patients, elderly patients, pregnant women, and nursing mothers have not been established conclusively. Use caution and individualize the dosage and administration based on the patient's age, weight, and medical condition.
How Supplied/Storage and Handling: L-Carnitine Injection is supplied as a sterile solution in vials or ampules for parenteral administration. It should be stored at controlled room temperature (20°C to 25°C) away from light and moisture. Care should be taken to ensure proper storage and handling to maintain the integrity of the product. Unused portions should be discarded according to standard procedures for biohazardous waste.