Kanamycin Sulphate Injection

Description

Product Description: Kanamycin Sulfate Injection is an antibiotic medication used for the treatment of various bacterial infections. It belongs to the class of antibiotics known as aminoglycosides and is particularly effective against gram-negative bacteria. Kanamycin Sulfate Injection provides a valuable therapeutic option for patients with infections caused by susceptible organisms.

Indications and Usage: Kanamycin Sulfate Injection is indicated for the treatment of serious bacterial infections caused by susceptible organisms, including respiratory tract infections, urinary tract infections, bloodstream infections, and infections of the skin and soft tissues.

Dosage and Administration: Dosage and administration of Kanamycin Sulfate Injection should be determined by a qualified healthcare professional based on factors such as the severity of the infection, the patient's age and weight, renal function, and the susceptibility of the causative bacteria. It is typically administered intravenously or intramuscularly.

Dosage Forms and Strengths: Kanamycin Sulfate Injection is available as a sterile solution for injection in vials containing various strengths, typically ranging from 500 mg to 1 gram per vial.

Contraindications: Kanamycin Sulfate Injection is contraindicated in patients with a known hypersensitivity to kanamycin or any component of the formulation. It should not be used in patients with a history of severe allergic reactions to aminoglycoside antibiotics.

Warnings and Precautions: Serious adverse reactions, including nephrotoxicity and ototoxicity, have been reported with the use of kanamycin. It should be used with caution in patients with renal impairment or pre-existing hearing loss. Regular monitoring of renal function and auditory function is recommended during treatment.

Adverse Reactions/Side Effects: Common adverse reactions associated with kanamycin include nausea, vomiting, diarrhea, and rash. Serious adverse effects may include nephrotoxicity, ototoxicity, and allergic reactions.

Drug Interactions: Kanamycin may interact with other medications, including other nephrotoxic or ototoxic drugs, which may potentiate the risk of adverse effects. Concurrent use with other aminoglycoside antibiotics should be avoided whenever possible.

Use In Specific Populations Description: Safety and efficacy of Kanamycin Sulfate Injection in pediatric patients, pregnant women, and nursing mothers have not been established. Caution should be exercised when administering to these populations, and the potential risks and benefits should be carefully considered.

Clinical Pharmacology: Kanamycin exerts its bactericidal effects by inhibiting bacterial protein synthesis, leading to cell death. It has a broad spectrum of activity primarily against gram-negative bacteria.

How Supplied/Storage and Handling: Kanamycin Sulfate Injection is supplied as a sterile solution for injection in single-dose vials. It should be stored at controlled room temperature (20°C to 25°C) and protected from light. Unused portions of the reconstituted solution should be discarded.