Flucloxacillin Injection

Description

Product Description: Flucloxacillin Injection is a narrow-spectrum antibiotic used for the treatment of bacterial infections caused by susceptible organisms. It belongs to the class of antibiotics known as penicillins and is particularly effective against penicillinase-producing staphylococci. Flucloxacillin Injection provides a valuable therapeutic option for patients with skin and soft tissue infections, respiratory tract infections, and other bacterial infections caused by susceptible organisms.

Indications and Usage: Flucloxacillin Injection is indicated for the treatment of infections caused by susceptible gram-positive bacteria, including skin and soft tissue infections, respiratory tract infections, bone and joint infections, and endocarditis.

Dosage and Administration: Dosage and administration of Flucloxacillin Injection should be determined by a qualified healthcare professional based on factors such as the severity of the infection, the patient's age and weight, renal function, and the susceptibility of the causative bacteria. It is typically administered intravenously over a period of 20 to 30 minutes.

Dosage Forms and Strengths: Flucloxacillin Injection is available as a sterile powder for reconstitution in vials containing various strengths, typically ranging from 250 mg to 2 grams per vial.

Contraindications: Flucloxacillin Injection is contraindicated in patients with a known hypersensitivity to flucloxacillin or any component of the formulation. It should not be used in patients with a history of severe allergic reactions to beta-lactam antibiotics, such as penicillins and cephalosporins.

Warnings and Precautions: Serious hypersensitivity reactions, including anaphylaxis, have been reported with the use of flucloxacillin. It should be used with caution in patients with a history of allergies, asthma, or other allergic conditions. Prolonged use may result in the overgrowth of non-susceptible organisms, including fungi. Clostridium difficile-associated diarrhea has been reported with the use of nearly all antibacterial agents, including flucloxacillin.

Adverse Reactions/Side Effects: Common adverse reactions associated with flucloxacillin include nausea, vomiting, diarrhea, and rash. Serious adverse reactions may include severe allergic reactions, nephrotoxicity, and hepatotoxicity.

Drug Interactions: Flucloxacillin may interact with other medications, including oral contraceptives, which may reduce their effectiveness. Concurrent use with other drugs that affect liver function may increase the risk of hepatotoxicity.

Use In Specific Populations Description: Safety and efficacy of Flucloxacillin Injection in pediatric patients, pregnant women, and nursing mothers have not been established. Caution should be exercised when administering to these populations, and the potential risks and benefits should be carefully considered.

How Supplied/Storage and Handling: Flucloxacillin Injection is supplied as a sterile powder in single-dose vials. It should be stored at controlled room temperature (20°C to 25°C) and protected from light. Reconstituted solutions should be used immediately or stored under refrigeration for up to 24 hours.