Dopamine Injection
- Packing: 5 Ml Ampoule.
- Available Strength : 40 Mg/Ml
Description
Product Description: Dopamine Injection is a sterile solution used for intravenous administration. It contains dopamine hydrochloride, a precursor to norepinephrine and epinephrine, and acts as an adrenergic agonist. It is primarily utilized for its positive inotropic and vasopressor effects in the management of various cardiovascular conditions.
Indications and Usage: Dopamine Injection is indicated for the correction of hemodynamic imbalances present in shock syndrome due to myocardial infarction, trauma, endotoxic septicemia, open-heart surgery, renal failure, and chronic cardiac decompensation as in congestive heart failure.
Dosage and Administration: The dosage of Dopamine Injection varies based on the patient's age, weight, and clinical condition. It is administered intravenously, with the rate of infusion adjusted according to the patient's response and vital signs. Initial dosing usually ranges from 1 to 5 mcg/kg/minute, titrated to achieve the desired hemodynamic effect.
Dosage Forms and Strengths: Dopamine Injection is available as a sterile solution in vials for intravenous administration. It is commonly supplied in concentrations of 40 mg/mL or 80 mg/mL.
Contraindications: Dopamine Injection is contraindicated in patients with pheochromocytoma, uncorrected tachyarrhythmias, and ventricular fibrillation. It should not be used in patients with hypersensitivity to any component of the formulation or in patients with occlusive vascular disease.
Warnings and Precautions: Use caution when administering Dopamine Injection to patients with hypertension, ventricular arrhythmias, or hyperthyroidism. Rapid infusion of dopamine may cause extravasation, leading to tissue necrosis. Avoid co-administration with monoamine oxidase inhibitors (MAOIs) and phenytoin due to potential interactions.
Adverse Reactions/Side Effects: Common adverse reactions associated with Dopamine Injection include tachycardia, ectopic beats, palpitations, anginal pain, and hypertension. Other side effects may include nausea, vomiting, headache, or allergic reactions. Serious adverse effects such as cardiac arrhythmias or myocardial ischemia may occur with high doses or rapid infusion.
Drug Interactions: Dopamine Injection may interact with other sympathomimetic agents, such as epinephrine or norepinephrine, leading to additive cardiovascular effects. Concurrent use with MAOIs, tricyclic antidepressants, or phenytoin may potentiate the effects of dopamine and increase the risk of adverse reactions.
Use In Specific Populations Description: Safety and efficacy of Dopamine Injection in pediatric patients, pregnant women, and nursing mothers have not been established. Use caution and consult with a healthcare professional before administering to individuals in these populations.
How Supplied/Storage and Handling: Dopamine Injection is supplied as a sterile solution in vials for intravenous administration. It should be stored at controlled room temperature (20°C to 25°C) away from light and moisture. Care should be taken to ensure proper storage and handling to maintain the integrity of the product. Unused portions should be discarded according to standard procedures for biohazardous waste.