Dobutamine Injection
- Packing: 20 ml Vial, 5 ml Ampoule.
- Available Strength : 250 mg, 20 ml, 40 mg/ml
Description
Product Description: Dobutamine Injection is a sterile, non-pyrogenic, and clear, colorless solution used for intravenous administration. It belongs to the class of medications known as sympathomimetic amines and is primarily used for its inotropic effect, enhancing cardiac contractility.
Indications and Usage: Dobutamine Injection is indicated for the short-term treatment of patients with cardiac decompensation due to depressed contractility, resulting from organic heart disease or surgical procedures. It is particularly useful in conditions such as congestive heart failure and cardiogenic shock.
Dosage and Administration: The dosage of Dobutamine Injection should be individualized based on the patient's condition, response to therapy, and concurrent medications. It is administered intravenously by continuous infusion, typically starting at a low dose and titrating upwards based on the patient's hemodynamic response.
Dosage Forms and Strengths: Dobutamine Injection is available as a sterile solution in vials or ampules for intravenous administration. It is commonly supplied in concentrations of 12.5 mg/mL or 50 mg/mL.
Contraindications: Dobutamine Injection is contraindicated in patients with idiopathic hypertrophic subaortic stenosis (IHSS) or those who have previously exhibited hypersensitivity to dobutamine or any of its components. It should not be used in patients with uncorrected tachyarrhythmias or ventricular fibrillation.
Warnings and Precautions: Use caution when administering Dobutamine Injection to patients with preexisting hypertension, as it may exacerbate elevated blood pressure. Continuous monitoring of heart rate, blood pressure, and cardiac rhythm is essential during infusion to avoid potential adverse effects such as tachycardia or arrhythmias. Dobutamine should be administered only by healthcare professionals experienced in the management of cardiac conditions.
Adverse Reactions/Side Effects: Adverse reactions associated with Dobutamine Injection may include palpitations, tachycardia, headache, nausea, vomiting, and hypertension. Arrhythmias, including ventricular ectopic activity, atrial fibrillation, and ventricular tachycardia, may also occur, particularly at higher infusion rates.
Drug Interactions: Dobutamine Injection may potentiate the effects of other sympathomimetic drugs, such as adrenaline and noradrenaline, leading to increased cardiovascular stimulation. Concurrent administration with monoamine oxidase inhibitors (MAOIs) may enhance the pressor effect of dobutamine, necessitating careful monitoring of blood pressure.
Use In Specific Populations Description: Safety and efficacy of Dobutamine Injection in pediatric patients, pregnant women, and nursing mothers have not been established. Use caution and consult with a healthcare professional before administering to individuals in these populations.
How Supplied/Storage and Handling: Dobutamine Injection is supplied as a sterile solution in vials or ampules for intravenous use. It should be stored at controlled room temperature (20°C to 25°C) away from light and moisture. Care should be taken to ensure proper storage and handling to maintain the integrity of the product. Unused portions should be discarded according to standard procedures for biohazardous waste.