Cloxacillin Injection

Description

Product Description: Cloxacillin Injection is a narrow-spectrum beta-lactam antibiotic used primarily in the treatment of infections caused by susceptible gram-positive bacteria. It belongs to the class of antibiotics known as penicillins and is particularly effective against staphylococcal infections, including those caused by beta-lactamase-producing strains. Cloxacillin Injection provides a valuable therapeutic option for patients with skin and soft tissue infections, respiratory tract infections, and other bacterial infections caused by susceptible organisms.

Indications and Usage: Cloxacillin Injection is indicated for the treatment of infections caused by susceptible gram-positive bacteria, including skin and soft tissue infections, respiratory tract infections, bone and joint infections, and endocarditis. It is particularly effective against infections caused by Staphylococcus aureus, including methicillin-sensitive strains.

Dosage and Administration: Dosage and administration of Cloxacillin Injection should be determined by a qualified healthcare professional based on factors such as the severity of the infection, the patient's age and weight, renal function, and the susceptibility of the causative bacteria. The recommended dosage regimen varies depending on the type and severity of the infection.

Dosage Forms and Strengths: Cloxacillin Injection is available as a sterile powder for reconstitution in vials containing various strengths, typically ranging from 250 mg to 1 gram per vial.

Contraindications: Cloxacillin Injection is contraindicated in patients with a known hypersensitivity to cloxacillin or any component of the formulation. It should not be used in patients with a history of severe allergic reactions to beta-lactam antibiotics, such as penicillins and cephalosporins.

Warnings and Precautions: Serious hypersensitivity reactions, including anaphylaxis, have been reported with the use of cloxacillin. It should be used with caution in patients with a history of allergies, asthma, or other allergic conditions. Prolonged use may result in the overgrowth of non-susceptible organisms, including fungi. Clostridium difficile-associated diarrhea has been reported with the use of nearly all antibacterial agents, including cloxacillin.

Adverse Reactions/Side Effects: Common adverse reactions associated with cloxacillin include diarrhea, nausea, vomiting, rash, and injection site reactions. Serious adverse reactions may include severe allergic reactions, nephrotoxicity, and hepatotoxicity.

Drug Interactions: Cloxacillin may interact with other medications, including oral contraceptives, which may reduce their effectiveness. Concurrent use with probenecid may increase cloxacillin plasma concentrations. Caution should be exercised when co-administering with other drugs that may affect renal function.

Use In Specific Populations Description: Use of Cloxacillin Injection in pregnant women should be weighed against the potential risks to the fetus. It is excreted in breast milk; caution should be exercised when administering to nursing mothers. Safety and efficacy in pediatric patients have been established for certain indications and age groups.

How Supplied/Storage and Handling: Cloxacillin Injection is supplied as a sterile powder in single-dose vials. It should be stored at controlled room temperature (20°C to 25°C) and protected from light. Reconstituted solutions should be used immediately or stored under refrigeration for up to 24 hours.