Chloramphenicol Sodium Succinate Injection

Description

Product Description: Chloramphenicol Sodium Succinate Injection is a broad-spectrum antibiotic used for the treatment of various bacterial infections. It contains chloramphenicol, a bacteriostatic antibiotic that inhibits protein synthesis in susceptible bacteria. Chloramphenicol Sodium Succinate Injection is available for intravenous administration and provides a valuable therapeutic option for patients with serious bacterial infections.

Indications and Usage: Chloramphenicol Sodium Succinate Injection is indicated for the treatment of serious bacterial infections caused by susceptible organisms, including respiratory tract infections, meningitis, septicemia, and other infections when less potentially hazardous therapeutic agents are ineffective or contraindicated.

Dosage and Administration: Dosage and administration should be determined by a qualified healthcare professional based on factors such as the severity of the infection, the patient's age and weight, renal function, and the susceptibility of the causative bacteria. Chloramphenicol Sodium Succinate Injection is typically administered intravenously over a period of 30 minutes to one hour.

Dosage Forms and Strengths: Chloramphenicol Sodium Succinate Injection is available as a sterile powder for reconstitution in vials containing various strengths, typically ranging from 500 mg to 1 gram per vial.

Contraindications: Chloramphenicol Sodium Succinate Injection is contraindicated in patients with a known hypersensitivity to chloramphenicol or any component of the formulation. It should not be used in patients with a history of bone marrow suppression or other significant hematologic disorders.

Warnings and Precautions: Serious adverse reactions, including bone marrow suppression, aplastic anemia, and gray baby syndrome, have been reported with the use of chloramphenicol. It should be used with caution in patients with pre-existing hematologic disorders or liver dysfunction. Regular monitoring of hematologic parameters is recommended during treatment.

Adverse Reactions/Side Effects: Common adverse reactions associated with chloramphenicol include nausea, vomiting, diarrhea, and headache. Serious adverse reactions may include bone marrow suppression, aplastic anemia, and hypersensitivity reactions.

Drug Interactions: Chloramphenicol may interact with other medications, including anticoagulants, which may potentiate or prolong their effects. Concurrent use with other drugs that suppress bone marrow function may increase the risk of hematologic toxicity.

Use In Specific Populations Description: Safety and efficacy of Chloramphenicol Sodium Succinate Injection in pediatric patients, pregnant women, and nursing mothers have not been established. Caution should be exercised when administering to these populations, and the potential risks and benefits should be carefully considered.

How Supplied/Storage and Handling: Chloramphenicol Sodium Succinate Injection is supplied as a sterile powder in single-dose vials. It should be stored at controlled room temperature (20°C to 25°C) and protected from light. Reconstituted solutions should be used immediately or stored under refrigeration for up to 24 hours.