Ceftriaxone Injection

Description

Product Description: Ceftriaxone Injection is a potent antibiotic used for the treatment of various bacterial infections. It belongs to the cephalosporin class of antibiotics, which are known for their broad-spectrum activity against a wide range of bacteria. This injectable medication is a crucial tool in combating infections, particularly those caused by gram-positive and gram-negative bacteria.

Indications and Usage: Ceftriaxone Injection is indicated for the treatment of bacterial infections caused by susceptible organisms. It is commonly prescribed for infections of the respiratory tract, urinary tract, skin and soft tissue, bones and joints, as well as for septicemia, meningitis, and intra-abdominal infections.

Dosage and Administration: Dosage and administration should be determined by a qualified healthcare professional based on the severity of the infection, the patient's age and weight, and the susceptibility of the causative bacteria. Ceftriaxone is typically administered intravenously or intramuscularly once or twice daily. Dosage adjustments may be necessary in patients with impaired renal function.

Dosage Forms and Strengths: Ceftriaxone Injection is available as a sterile powder for reconstitution in various strengths, typically ranging from 250 mg to 2 grams per vial.

Contraindications: Ceftriaxone Injection is contraindicated in patients with known hypersensitivity to cephalosporin antibiotics or any component of the formulation. It should not be used in patients with a history of severe allergic reactions to penicillin or other beta-lactam antibiotics.

Warnings and Precautions: Serious hypersensitivity reactions, including anaphylaxis, have been reported with the use of ceftriaxone. It should be used with caution in patients with a history of allergies, asthma, or other allergic conditions. Prolonged use may result in the overgrowth of non-susceptible organisms, including fungi. Clostridium difficile-associated diarrhea has been reported with the use of nearly all antibacterial agents, including ceftriaxone.

Adverse Reactions/Side Effects: Common adverse reactions associated with ceftriaxone include diarrhea, nausea, vomiting, rash, and injection site reactions. Serious adverse reactions may include severe allergic reactions, Clostridium difficile-associated diarrhea, and hepatic dysfunction.

Drug Interactions: Ceftriaxone may interact with other medications, including probenecid, which may increase the serum concentration of ceftriaxone by reducing renal excretion. Concurrent use with calcium-containing intravenous solutions may result in precipitation and should be avoided.

Use In Specific Populations: Use of ceftriaxone in pregnant women should be weighed against the potential risks to the fetus. It is excreted in breast milk; caution should be exercised when administering to nursing mothers. Safety and effectiveness in pediatric patients have been established for certain indications and age groups.

How Supplied/Storage and Handling: Ceftriaxone Injection is supplied as sterile powder in single-dose vials. It should be stored at controlled room temperature (20°C to 25°C) and protected from light.