Ceftriaxone + Sulbactam Injection

Description

Product Description: Ceftriaxone + Sulbactam Injection combines the potent antibiotic ceftriaxone with the beta-lactamase inhibitor sulbactam, providing a synergistic effect in the treatment of bacterial infections. This combination therapy is designed to enhance the antibacterial activity of ceftriaxone by preventing the destruction of the antibiotic by beta-lactamase enzymes produced by certain bacteria.

Indications and Usage: Ceftriaxone + Sulbactam Injection is indicated for the treatment of bacterial infections caused by susceptible organisms. It is particularly effective against infections of the respiratory tract, urinary tract, skin and soft tissue, bones and joints, as well as for intra-abdominal infections, septicemia, and meningitis.

Dosage and Administration: Dosage and administration should be determined by a qualified healthcare professional based on the severity of the infection, the patient's age and weight, and the susceptibility of the causative bacteria. Ceftriaxone + Sulbactam is typically administered intravenously or intramuscularly once or twice daily. Dosage adjustments may be necessary in patients with impaired renal function.

Dosage Forms and Strengths: Ceftriaxone + Sulbactam Injection is available as a sterile powder for reconstitution in various strengths, typically ranging from 1 gram of ceftriaxone combined with 0.5 grams of sulbactam to 2 grams of ceftriaxone combined with 1 gram of sulbactam per vial.

Contraindications: Ceftriaxone + Sulbactam Injection is contraindicated in patients with known hypersensitivity to cephalosporin antibiotics, beta-lactamase inhibitors, or any component of the formulation. It should not be used in patients with a history of severe allergic reactions to penicillin or other beta-lactam antibiotics.

Warnings and Precautions: Serious hypersensitivity reactions, including anaphylaxis, have been reported with the use of ceftriaxone + sulbactam. It should be used with caution in patients with a history of allergies, asthma, or other allergic conditions. Prolonged use may result in the overgrowth of non-susceptible organisms, including fungi. Clostridium difficile-associated diarrhea has been reported with the use of nearly all antibacterial agents, including ceftriaxone + sulbactam.

Adverse Reactions/Side Effects: Common adverse reactions associated with ceftriaxone + sulbactam include diarrhea, nausea, vomiting, rash, and injection site reactions. Serious adverse reactions may include severe allergic reactions, Clostridium difficile-associated diarrhea, and hepatic dysfunction.

Drug Interactions: Ceftriaxone + Sulbactam may interact with other medications, including probenecid, which may increase the serum concentration of ceftriaxone by reducing renal excretion. Concurrent use with calcium-containing intravenous solutions may result in precipitation and should be avoided.

Use In Specific Populations Description: Use of ceftriaxone + sulbactam in pregnant women should be weighed against the potential risks to the fetus. It is excreted in breast milk; caution should be exercised when administering to nursing mothers. Safety and effectiveness in pediatric patients have been established for certain indications and age groups.

How Supplied/Storage and Handling: Ceftriaxone + Sulbactam Injection is supplied as sterile powder in single-dose vials. It should be stored at controlled room temperature (20°C to 25°C) and protected from light.