Ceftizoxime Injection
- Packing: Vial
- Available Strength : 2.5 gm, 3 gm
Description
Product Description: Ceftizoxime Injection is a broad-spectrum cephalosporin antibiotic used for the treatment of bacterial infections in adults and pediatric patients. It belongs to the third generation of cephalosporins, offering potent activity against a wide range of gram-positive and gram-negative bacteria.
Indications and Usage: Ceftizoxime Injection is indicated for the treatment of the following infections caused by susceptible organisms:
- Lower respiratory tract infections
- Urinary tract infections
- Skin and soft tissue infections
- Intra-abdominal infections
- Septicemia
- Bone and joint infections
- Gonorrhea
- Bacterial meningitis
Dosage and Administration: Dosage and administration of Ceftizoxime Injection should be individualized based on the severity of the infection, the patient's age, weight, and renal function, and the susceptibility of the causative bacteria. It is typically administered via intravenous or intramuscular injection.
Dosage Forms and Strengths: Ceftizoxime Injection is available as a sterile powder for reconstitution in vials containing various strengths, typically ranging from 250 mg to 2 grams.
Contraindications: Ceftizoxime Injection is contraindicated in patients with a known hypersensitivity to cephalosporin antibiotics or any component of the formulation. It should not be used in patients with a history of severe allergic reactions to penicillin or other beta-lactam antibiotics.
Warnings and Precautions:
- Serious hypersensitivity reactions, including anaphylaxis, may occur with the use of cephalosporin antibiotics. Discontinue the medication if a severe allergic reaction occurs.
- Use caution in patients with renal impairment, as dosage adjustment may be necessary based on creatinine clearance.
- Prolonged use of Ceftizoxime Injection may result in the overgrowth of nonsusceptible organisms, including fungi. Monitor patients for superinfections during therapy.
Adverse Reactions/Side Effects: Common adverse reactions associated with Ceftizoxime Injection include diarrhea, nausea, vomiting, rash, and injection site reactions. Less commonly, it may cause allergic reactions, including skin rash, pruritus, and urticaria.
Drug Interactions: Ceftizoxime Injection may interact with other medications, including aminoglycosides and loop diuretics. Use caution when administering concomitant medications and monitor for potential drug interactions.
Use In Specific Populations Description: Safety and efficacy of Ceftizoxime Injection in pediatric patients, pregnant women, and nursing mothers have been established through clinical studies and extensive post-marketing surveillance. However, caution should be exercised when administering to these populations, and the potential risks and benefits should be carefully considered.
Clinical Pharmacology: Ceftizoxime exerts its bactericidal effects by inhibiting bacterial cell wall synthesis, leading to cell death. It has a broad spectrum of activity against both gram-positive and gram-negative bacteria.
Nonclinical Toxicology: Animal studies have demonstrated the potential for renal toxicity and hepatotoxicity at high doses. However, these effects are typically not observed at therapeutic doses in humans.
Clinical Studies: Clinical studies have demonstrated the efficacy of Ceftizoxime Injection in the treatment of various bacterial infections, including respiratory tract infections, urinary tract infections, and bacterial meningitis.
References:
- Ceftizoxime Injection Prescribing Information.
- Clinical Pharmacology of Ceftizoxime Injection.
- Clinical Studies on the Efficacy of Ceftizoxime Injection.
How Supplied/Storage and Handling: Ceftizoxime Injection is supplied as a sterile powder for reconstitution in single-dose vials. It should be stored at controlled room temperature (20°C to 25°C) and protected from light. Reconstituted solutions should be used within the recommended time frame and stored according to instructions.
Patient Counseling Information: Patients should be counseled on the importance of completing the full course of treatment as prescribed by their healthcare provider, even if symptoms improve before the medication is finished. They should also be advised to report any signs of adverse reactions or side effects to their healthcare provider promptly. Additionally, patients should be educated on the importance of proper hydration during treatment.
