Cefotaxime Injection

Description

Product Description: Cefotaxime Injection is a potent antibiotic belonging to the cephalosporin class. It is formulated to combat a wide range of bacterial infections, offering bactericidal activity against both gram-positive and gram-negative organisms. Cefotaxime is an essential therapeutic option for various infections, including respiratory tract infections, urinary tract infections, skin and soft tissue infections, intra-abdominal infections, septicemia, and bacterial meningitis.

Indications and Usage: Cefotaxime Injection is indicated for the treatment of moderate to severe bacterial infections caused by susceptible organisms. It is commonly prescribed for infections of the respiratory tract, urinary tract, skin and soft tissue, bones and joints, and intra-abdominal infections.

Dosage and Administration: Dosage and administration should be determined by a qualified healthcare professional based on factors such as the severity of the infection, the patient's age and weight, and the susceptibility of the causative bacteria. Cefotaxime is typically administered intravenously or intramuscularly at intervals ranging from every 6 to 8 hours.

Dosage Forms and Strengths: Cefotaxime Injection is available as a sterile powder for reconstitution in various strengths, typically ranging from 500 mg to 2 grams per vial.

Contraindications: Cefotaxime Injection is contraindicated in patients with known hypersensitivity to cephalosporin antibiotics or any component of the formulation. It should not be used in patients with a history of severe allergic reactions to penicillin or other beta-lactam antibiotics.

Warnings and Precautions: Serious hypersensitivity reactions, including anaphylaxis, have been reported with the use of cefotaxime. It should be used with caution in patients with a history of allergies, asthma, or other allergic conditions. Prolonged use may result in the overgrowth of non-susceptible organisms, including fungi. Clostridium difficile-associated diarrhea has been reported with the use of nearly all antibacterial agents, including cefotaxime.

Adverse Reactions/Side Effects: Common adverse reactions associated with cefotaxime include diarrhea, nausea, vomiting, rash, and injection site reactions. Serious adverse reactions may include severe allergic reactions, Clostridium difficile-associated diarrhea, and hepatic dysfunction.

Drug Interactions: Cefotaxime may interact with other medications, including aminoglycosides, which may potentiate nephrotoxicity. Concurrent use with loop diuretics may increase the risk of nephrotoxicity. Caution should be exercised when co-administering with other nephrotoxic drugs.

Use In Specific Populations Description: Use of cefotaxime in pregnant women should be weighed against the potential risks to the fetus. It is excreted in breast milk; caution should be exercised when administering to nursing mothers. Safety and effectiveness in pediatric patients have been established for certain indications and age groups.

How Supplied/Storage and Handling: Cefotaxime Injection is supplied as sterile powder in single-dose vials. It should be stored at controlled room temperature (20°C to 25°C) and protected from light.