Cefotaxime + Sulbactam Injection

Description

Product Description: Cefotaxime + Sulbactam Injection is a powerful combination antibiotic comprising cefotaxime, a third-generation cephalosporin, and sulbactam, a beta-lactamase inhibitor. This combination therapy offers broad-spectrum activity against a wide range of bacterial infections, including those caused by beta-lactamase-producing organisms. Cefotaxime + Sulbactam Injection is formulated to address complicated infections where resistance is a concern.

Indications and Usage: Cefotaxime + Sulbactam Injection is indicated for the treatment of moderate to severe bacterial infections caused by susceptible organisms. It is commonly prescribed for infections of the respiratory tract, urinary tract, skin and soft tissue, intra-abdominal infections, septicemia, and bacterial meningitis.

Dosage and Administration: Dosage and administration should be determined by a qualified healthcare professional based on factors such as the severity of the infection, the patient's age and weight, and the susceptibility of the causative bacteria. Cefotaxime + Sulbactam is typically administered intravenously at intervals ranging from every 6 to 8 hours.

Dosage Forms and Strengths: Cefotaxime + Sulbactam Injection is available as a sterile powder for reconstitution in various strengths, typically ranging from 1.5 grams to 3 grams per vial.

Contraindications: Cefotaxime + Sulbactam Injection is contraindicated in patients with known hypersensitivity to cephalosporin antibiotics, beta-lactamase inhibitors, or any component of the formulation. It should not be used in patients with a history of severe allergic reactions to penicillin or other beta-lactam antibiotics.

Warnings and Precautions: Serious hypersensitivity reactions, including anaphylaxis, have been reported with the use of cefotaxime + sulbactam. It should be used with caution in patients with a history of allergies, asthma, or other allergic conditions. Prolonged use may result in the overgrowth of non-susceptible organisms, including fungi. Clostridium difficile-associated diarrhea has been reported with the use of nearly all antibacterial agents, including cefotaxime + sulbactam.

Adverse Reactions/Side Effects: Common adverse reactions associated with cefotaxime + sulbactam include diarrhea, nausea, vomiting, rash, and injection site reactions. Serious adverse reactions may include severe allergic reactions, Clostridium difficile-associated diarrhea, and hepatic dysfunction.

Drug Interactions: Cefotaxime + Sulbactam may interact with other medications, including aminoglycosides, which may potentiate nephrotoxicity. Concurrent use with loop diuretics may increase the risk of nephrotoxicity. Caution should be exercised when co-administering with other nephrotoxic drugs.

Use In Specific Populations Description: Use of cefotaxime + sulbactam in pregnant women should be weighed against the potential risks to the fetus. It is excreted in breast milk; caution should be exercised when administering to nursing mothers. Safety and effectiveness in pediatric patients have been established for certain indications and age groups.

How Supplied/Storage and Handling: Cefotaxime + Sulbactam Injection is supplied as sterile powder in single-dose vials. It should be stored at controlled room temperature (20°C to 25°C) and protected from light.