Capreomycin Injection

Description

Product Description: Capreomycin Injection is a potent antibiotic medication used primarily in the treatment of multidrug-resistant tuberculosis (MDR-TB). It belongs to the class of antibiotics known as aminoglycosides and is administered intramuscularly or intravenously. Capreomycin Injection is a crucial component of MDR-TB treatment regimens and plays a vital role in combating tuberculosis infections that are resistant to first-line therapies.

Indications and Usage: Capreomycin Injection is indicated for the treatment of tuberculosis infections caused by Mycobacterium tuberculosis strains that are resistant to first-line anti-tuberculosis medications. It is typically reserved for use in patients with multidrug-resistant tuberculosis (MDR-TB) or in cases where other first-line therapies have failed.

Dosage and Administration: Dosage and administration of Capreomycin Injection should be determined by a qualified healthcare professional experienced in the treatment of tuberculosis. The recommended dosage regimen varies depending on the severity of the infection, the patient's weight, renal function, and other factors.

Dosage Forms and Strengths: Capreomycin Injection is available as a sterile powder for reconstitution in vials containing 1 gram of capreomycin sulfate.

Contraindications: Capreomycin Injection is contraindicated in patients with known hypersensitivity to capreomycin or any component of the formulation. It should not be used in patients with pre-existing auditory or vestibular dysfunction.

Warnings and Precautions: Capreomycin Injection should be used with caution in patients with pre-existing renal impairment or hearing impairment. Auditory and vestibular function should be monitored regularly during treatment. Capreomycin may cause nephrotoxicity and neurotoxicity, particularly when administered with other nephrotoxic or neurotoxic medications.

Adverse Reactions/Side Effects: Common adverse reactions associated with Capreomycin Injection include nephrotoxicity, ototoxicity (including hearing loss and balance disturbances), electrolyte disturbances, and injection site reactions. Less common but serious adverse reactions may include renal failure and neurotoxicity.

Drug Interactions: Capreomycin may interact with other medications, particularly those with nephrotoxic or neurotoxic potential. Concurrent use with other aminoglycosides or nephrotoxic medications should be avoided or closely monitored.

Use In Specific Populations Description: Safety and efficacy of Capreomycin Injection in pediatric patients, pregnant women, and nursing mothers have not been established. Caution should be exercised when administering to these populations, and the potential risks and benefits should be carefully considered.

How Supplied/Storage and Handling: Capreomycin Injection is supplied as a sterile powder in single-dose vials. It should be stored at controlled room temperature (20°C to 25°C) and protected from light. Reconstituted solutions should be used immediately or stored under refrigeration for up to 24 hours.