Aztreonam Injection

Description

Product Description: Aztreonam Injection is a monobactam antibiotic used for the treatment of serious bacterial infections. It exhibits potent activity against gram-negative bacteria, making it particularly useful in infections caused by multidrug-resistant organisms. Aztreonam Injection offers a valuable therapeutic option for patients with complex infections where other antibiotics may be ineffective.

Indications and Usage: Aztreonam Injection is indicated for the treatment of infections caused by susceptible gram-negative bacteria, including urinary tract infections, lower respiratory tract infections, intra-abdominal infections, skin and skin structure infections, and gynecological infections.

Dosage and Administration: Dosage and administration should be determined by a qualified healthcare professional based on factors such as the severity of the infection, the patient's age and weight, renal function, and the susceptibility of the causative bacteria. Aztreonam is typically administered intravenously over a period of 20 to 60 minutes.

Dosage Forms and Strengths: Aztreonam Injection is available as a sterile powder for reconstitution in various strengths, typically ranging from 500 mg to 2 grams per vial.

Contraindications: Aztreonam Injection is contraindicated in patients with a known hypersensitivity to aztreonam or any component of the formulation. It should not be used in patients with a history of severe allergic reactions to beta-lactam antibiotics, such as penicillins and cephalosporins.

Warnings and Precautions: Serious hypersensitivity reactions, including anaphylaxis, have been reported with the use of aztreonam. It should be used with caution in patients with a history of allergies, asthma, or other allergic conditions. Prolonged use may result in the overgrowth of non-susceptible organisms, including fungi. Clostridium difficile-associated diarrhea has been reported with the use of nearly all antibacterial agents, including aztreonam.

Adverse Reactions/Side Effects: Common adverse reactions associated with aztreonam include diarrhea, nausea, vomiting, rash, and injection site reactions. Serious adverse reactions may include severe allergic reactions, nephrotoxicity, and hepatotoxicity.

Drug Interactions: Aztreonam may interact with other medications, including nephrotoxic drugs such as aminoglycosides and loop diuretics, which may increase the risk of kidney damage. Concurrent use with other drugs that may affect renal function may also increase the risk of nephrotoxicity.

Use In Specific Populations Description: Use of Aztreonam Injection in pregnant women should be weighed against the potential risks to the fetus. It is excreted in breast milk; caution should be exercised when administering to nursing mothers. Safety and efficacy in pediatric patients have been established for certain indications and age groups.

How Supplied/Storage and Handling: Aztreonam Injection is supplied as a sterile powder in single-dose vials. It should be stored at controlled room temperature (20°C to 25°C) and protected from light. Reconstituted solutions should be used immediately or stored under refrigeration for up to 24 hours.