Atropine Injection
- Packing: 1 Ml Ampoule, 10 Ml Vial.
- Available Strength : 0.6 Mg/Ml, 0.5 mg/ml, 1 mg/ml
Description
Product Description: Atropine Injection is a sterile, non-pyrogenic solution used for intravenous or intramuscular administration. It belongs to the class of anticholinergic agents and is derived from the belladonna alkaloids. Atropine Injection is commonly used to treat bradycardia, as a preanesthetic to reduce salivation and bronchial secretions, and as an antidote for certain types of poisoning.
Indications and Usage: Atropine Injection is indicated for the treatment of bradycardia, where increased heart rate is clinically indicated. It is also used as a preanesthetic to reduce salivary, tracheobronchial, and pharyngeal secretions. Additionally, Atropine Injection is employed as an antidote for organophosphate poisoning, such as from pesticides or nerve agents.
Dosage and Administration: The dosage of Atropine Injection varies depending on the indication and patient's response to therapy. For bradycardia, the usual adult dose is 0.5 to 1 mg intravenously, repeated as needed every 3 to 5 minutes, up to a maximum total dose of 3 mg. For preanesthetic use, the dose is typically 0.4 to 0.6 mg intramuscularly administered 30 to 60 minutes before surgery. In cases of organophosphate poisoning, higher doses may be required, administered intravenously as determined by the severity of symptoms.
Dosage Forms and Strengths: Atropine Injection is available as a sterile solution in vials or ampules for intravenous or intramuscular use. It is commonly supplied in concentrations of 0.1 mg/mL or 1 mg/mL.
Contraindications: Atropine Injection is contraindicated in patients with narrow-angle glaucoma, obstructive uropathy, obstructive gastrointestinal disorders, severe ulcerative colitis, myasthenia gravis, or known hypersensitivity to atropine or its derivatives.
Warnings and Precautions: Use caution when administering Atropine Injection to elderly patients, as they may be more sensitive to its effects. Atropine may cause tachycardia, dry mouth, blurred vision, and urinary retention. Monitor patients closely for signs of anticholinergic toxicity, especially in those with underlying cardiac or pulmonary disease.
Adverse Reactions/Side Effects: Common adverse reactions associated with Atropine Injection include dry mouth, blurred vision, urinary retention, constipation, and tachycardia. Less frequently, it may cause agitation, confusion, hallucinations, or delirium.
Drug Interactions: Atropine Injection may interact with other medications that have anticholinergic effects, such as tricyclic antidepressants, antihistamines, or antipsychotics. Concurrent use with drugs that increase heart rate or have sympathomimetic activity may potentiate tachycardia.
Use In Specific Populations Description: Safety and efficacy of Atropine Injection in pediatric patients, pregnant women, and nursing mothers have not been established. Use caution and consult with a healthcare professional before administering to individuals in these populations.
How Supplied/Storage and Handling: Atropine Injection is supplied as a sterile solution in vials or ampules for intravenous or intramuscular use. It should be stored at controlled room temperature (20°C to 25°C) away from light and moisture. Care should be taken to ensure proper storage and handling to maintain the integrity of the product. Unused portions should be discarded according to standard procedures for biohazardous waste.