Ampicillin Injection

Description

Product Description: Ampicillin Injection is a broad-spectrum penicillin antibiotic used for the treatment of various bacterial infections. It is effective against both gram-positive and gram-negative bacteria and is particularly useful in treating respiratory, urinary tract, skin and soft tissue, and gastrointestinal infections. Ampicillin Injection is an essential tool in the fight against bacterial infections, providing rapid and effective relief to patients in need.

Indications and Usage: Ampicillin Injection is indicated for the treatment of susceptible bacterial infections, including respiratory tract infections, urinary tract infections, skin and soft tissue infections, bacterial meningitis, and endocarditis.

Dosage and Administration: Dosage and administration of Ampicillin Injection should be determined by a healthcare professional based on the severity of the infection, the patient's age, weight, and renal function, and the susceptibility of the causative bacteria. It is typically administered intravenously or intramuscularly.

Dosage Forms and Strengths: Ampicillin Injection is available as a sterile powder for reconstitution in various strengths, typically ranging from 250 mg to 2 grams per vial.

Contraindications: Ampicillin Injection is contraindicated in patients with a known hypersensitivity to penicillins or any component of the formulation. It should not be used in patients with a history of severe allergic reactions to beta-lactam antibiotics, such as penicillins and cephalosporins.

Warnings and Precautions: Serious hypersensitivity reactions, including anaphylaxis, have been reported with the use of ampicillin. It should be used with caution in patients with a history of allergies, asthma, or other allergic conditions. Prolonged use may result in the overgrowth of non-susceptible organisms, including fungi. Clostridium difficile-associated diarrhea has been reported with the use of nearly all antibacterial agents, including ampicillin.

Adverse Reactions/Side Effects: Common adverse reactions associated with ampicillin include diarrhea, nausea, vomiting, rash, and injection site reactions. Serious adverse reactions may include severe allergic reactions, nephrotoxicity, and hepatotoxicity.

Drug Interactions: Ampicillin may interact with other medications, including oral contraceptives, which may reduce their effectiveness. Concurrent use with probenecid may increase ampicillin plasma concentrations. Caution should be exercised when co-administering with other drugs that may affect renal function.

Use In Specific Populations Description: Use of Ampicillin Injection in pregnant women should be weighed against the potential risks to the fetus. It is excreted in breast milk; caution should be exercised when administering to nursing mothers. Safety and efficacy in pediatric patients have been established for certain indications and age groups.

How Supplied/Storage and Handling: Ampicillin Injection is supplied as a sterile powder in single-dose vials. It should be stored at controlled room temperature (20°C to 25°C) and protected from light. Reconstituted solutions should be used immediately or stored under refrigeration for up to 24 hours.