Nicardipine Injection
- Packing: 10 Ml Ampoule.
- Available Strength : 1 Mg/Ml
Description
Product Description: Nicardipine Injection is a sterile solution for intravenous administration. It belongs to the class of medications known as calcium channel blockers and is primarily used for the treatment of hypertension, angina, and certain cardiac conditions. This medication works by relaxing blood vessels, thereby improving blood flow and reducing blood pressure.
Indications and Usage: Nicardipine Injection is indicated for the treatment of hypertension, including hypertensive emergencies and perioperative hypertension. It may also be used in the management of angina pectoris, including variant angina (Prinzmetal's or vasospastic angina).
Dosage and Administration: The dosage of Nicardipine Injection varies depending on the indication, patient's clinical status, and response to therapy. The usual adult dose for hypertensive emergencies ranges from 5 to 15 mg/hour administered by continuous intravenous infusion. For angina, the initial dose is typically 5 mg administered intravenously over 5 minutes, followed by continuous infusion if needed.
Dosage Forms and Strengths: Nicardipine Injection is available as a sterile solution in vials for intravenous administration. It is commonly supplied in concentrations of 2.5 mg/mL.
Contraindications: Nicardipine Injection is contraindicated in patients with known hypersensitivity to nicardipine or any component of the formulation. It should not be used in patients with advanced aortic stenosis or acute myocardial infarction with hypotension.
Warnings and Precautions: Use caution when administering Nicardipine Injection to patients with impaired hepatic function or heart failure, as it may exacerbate these conditions. Monitor patients closely for signs of hypotension, reflex tachycardia, or other adverse reactions during therapy. Avoid abrupt discontinuation of therapy, as it may lead to rebound hypertension.
Adverse Reactions/Side Effects: Common adverse reactions associated with Nicardipine Injection include hypotension, headache, flushing, and peripheral edema. Less frequently, it may cause dizziness, nausea, vomiting, or palpitations. Serious adverse effects such as myocardial infarction or arrhythmias may occur with prolonged use.
Drug Interactions: Nicardipine Injection may interact with other medications that affect blood pressure or cardiac function, such as beta-blockers, diuretics, or antiarrhythmic agents. Concurrent use with these drugs may potentiate or antagonize the effects of nicardipine.
Use In Specific Populations Description: Safety and efficacy of Nicardipine Injection in pediatric patients, pregnant women, and nursing mothers have not been established. Use caution and consult with a healthcare professional before administering to individuals in these populations.
How Supplied/Storage and Handling: Nicardipine Injection is supplied as a sterile solution in vials for intravenous administration. It should be stored at controlled room temperature (20°C to 25°C) away from light and moisture. Care should be taken to ensure proper storage and handling to maintain the integrity of the product. Unused portions should be discarded according to standard procedures for biohazardous waste.