Hydralazine Hydrochloride Injection
- Packing: 1 Ml Ampoule.
- Available Strength : 20 Mg/Ml
Description
Product Description: Hydralazine Hydrochloride Injection is a sterile solution for intravenous use. It belongs to the class of medications known as vasodilators and is primarily used to treat hypertension. This medication works by relaxing blood vessels, thereby lowering blood pressure and improving blood flow.
Indications and Usage: Hydralazine Hydrochloride Injection is indicated for the treatment of moderate to severe hypertension in situations where oral therapy is not feasible or desirable. It may also be used as adjunctive therapy in the management of heart failure.
Dosage and Administration: The dosage of Hydralazine Hydrochloride Injection varies depending on the indication and patient's response to therapy. The usual adult dose for hypertension is 10 to 20 mg administered intravenously every 4 to 6 hours as needed, with careful monitoring of blood pressure. In heart failure, doses may range from 20 to 40 mg administered intravenously every 4 to 6 hours.
Dosage Forms and Strengths: Hydralazine Hydrochloride Injection is available as a sterile solution in vials for intravenous administration. It is commonly supplied in concentrations of 20 mg/mL.
Contraindications: Hydralazine Hydrochloride Injection is contraindicated in patients with known hypersensitivity to hydralazine or any component of the formulation. It should not be used in individuals with coronary artery disease, mitral valvular rheumatic heart disease, or known hypersensitivity to other hydrazine derivatives.
Warnings and Precautions: Use caution when administering Hydralazine Hydrochloride Injection to patients with impaired hepatic function, as it may exacerbate liver dysfunction. Monitor patients closely for signs of hypotension, tachycardia, or reflex tachycardia during therapy. Avoid abrupt discontinuation of therapy, as it may lead to rebound hypertension.
Adverse Reactions/Side Effects: Common adverse reactions associated with Hydralazine Hydrochloride Injection include hypotension, tachycardia, headache, and flushing. Less frequently, it may cause palpitations, nausea, vomiting, or diarrhea. Serious adverse effects such as myocardial ischemia or lupus-like syndrome may occur with prolonged use.
Drug Interactions: Hydralazine Hydrochloride Injection may interact with other medications that affect blood pressure or cardiac function, such as beta-blockers, diuretics, or calcium channel blockers. Concurrent use with these drugs may potentiate or antagonize the effects of hydralazine.
Use In Specific Populations Description: Safety and efficacy of Hydralazine Hydrochloride Injection in pediatric patients, pregnant women, and nursing mothers have not been established. Use caution and consult with a healthcare professional before administering to individuals in these populations.
How Supplied/Storage and Handling: Hydralazine Hydrochloride Injection is supplied as a sterile solution in vials for intravenous administration. It should be stored at controlled room temperature (20°C to 25°C) away from light and moisture. Care should be taken to ensure proper storage and handling to maintain the integrity of the product. Unused portions should be discarded according to standard procedures for biohazardous waste.