Ceftiofur Injection
- Packing: Vial
- Available Strength : 250 mg, 500 gm, 1 gm
Description
Product Description: Ceftiofur Injection is a potent third-generation cephalosporin antibiotic used for the treatment of bacterial infections in various animal species. It belongs to the beta-lactam class of antibiotics and exhibits broad-spectrum activity against both gram-positive and gram-negative bacteria.
Indications and Usage: Ceftiofur Injection is indicated for the treatment of the following infections in cattle, swine, sheep, and goats caused by susceptible organisms:
- Respiratory tract infections
- Metritis
- Foot rot
- Skin and soft tissue infections
- Systemic infections
Dosage and Administration: Dosage and administration of Ceftiofur Injection should be determined by a qualified veterinarian based on the severity of the infection, the weight and species of the animal, and the susceptibility of the causative bacteria. It is typically administered via intramuscular or subcutaneous injection.
Dosage Forms and Strengths: Ceftiofur Injection is available as a sterile solution for injection in vials containing various strengths, typically ranging from 50 mg/mL to 200 mg/mL.
Contraindications: Ceftiofur Injection is contraindicated in animals with a known hypersensitivity to cephalosporin antibiotics or any component of the formulation. It should not be used in animals with a history of severe allergic reactions to penicillin or other beta-lactam antibiotics.
Warnings and Precautions:
- Serious hypersensitivity reactions, including anaphylaxis, may occur with the use of cephalosporin antibiotics. Discontinue the medication if a severe allergic reaction occurs.
- Use caution in animals with renal impairment or those receiving concurrent nephrotoxic medications.
- Long-term use of cephalosporin antibiotics may result in the development of antibiotic-resistant bacteria.
Adverse Reactions/Side Effects: Common adverse reactions associated with Ceftiofur Injection include diarrhea, vomiting, decreased appetite, and injection site reactions. Less commonly, it may cause allergic reactions, including skin rash, itching, and swelling.
Drug Interactions: Ceftiofur Injection may interact with other medications, including aminoglycosides and loop diuretics. Use caution when administering concomitant medications and monitor for potential drug interactions.
Use In Specific Populations Description: Safety and efficacy of Ceftiofur Injection in pregnant or lactating animals have not been established. Use only when the benefits outweigh the potential risks to the mother and offspring.
Clinical Pharmacology: Ceftiofur exerts its bactericidal effects by inhibiting bacterial cell wall synthesis, leading to cell death. It has a broad spectrum of activity against both gram-positive and gram-negative bacteria.
Nonclinical Toxicology: Animal studies have demonstrated the potential for renal toxicity and hepatotoxicity at high doses. However, these effects are typically not observed at therapeutic doses in animals.
Clinical Studies: Clinical studies have demonstrated the efficacy of Ceftiofur Injection in the treatment of various bacterial infections in cattle, swine, sheep, and goats.
References:
- Ceftiofur Injection Prescribing Information.
- Clinical Pharmacology of Ceftiofur Injection.
- Clinical Studies on the Efficacy of Ceftiofur Injection.
How Supplied/Storage and Handling: Ceftiofur Injection is supplied as a sterile solution for injection in single-dose vials. It should be stored at controlled room temperature (20°C to 25°C) and protected from light. Avoid freezing. Discard any unused portion of the product according to local regulations.
Patient Counseling Information: There is no patient counseling information for Ceftiofur Injection as it is intended for veterinary use only. Veterinarians should inform animal owners or caretakers about the importance of completing the full course of treatment and the potential for adverse reactions.
